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咖啡或茶,与ALS发病都没什么关系 (转载)

发表者:樊东升 人已读

EPIDEMIOLOGY

Intakes of caffeine, coffee and tea and risk of amyotrophic lateral sclerosis: Results from five cohort studies

Elinor Fondella*éIlis J. O’ReillyaKathryn C. FitzgeraldaGuido J. FalconebcLaurence N. KoloneldYikyung ParkefSusan M. Gapsturg &Alberto Ascherioabh北京大学第三医院神经内科樊东升

Caffeine is thought to be neuroprotective by antagonizing the adenosine A2Areceptors in the brain and thereby protecting motor neurons from excitotoxicity. We examined the association between consumption of caffeine, coffee and tea and risk of ALS.

Longitudinal analyses based on over 1,010,000 males and females in five large cohort studies (the Nurses’ Health Study, the Health Professionals Follow-up Study, the Cancer Prevention Study II Nutrition Cohort, the Multiethnic Cohort Study, and the National Institutes of Health-AARP Diet and Health Study). Cohort-specific multivariable-adjusted risk ratios (RR) and 95% confidence intervals (CI) estimates of ALS incidence or death were estimated by Cox proportional hazards regression and pooled using random-effects models. Results showed that a total of 1279 cases of ALS were documented during a mean of 18 years of follow-up. Caffeine intake was not associated with ALS risk; the pooled multivariable-adjusted RR comparing the highest to the lowest quintile of intake was 0.96 (95% CI 0.81–1.16). Similarly, neither coffee nor tea was associated with ALS risk. In conclusion, the results of this large study do not support associations of caffeine or caffeinated beverages with ALS risk.


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发表于:2015-11-29 15:23

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