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学术前沿

长期的锻炼可以有效的改善线粒体病患者的运动能力,而且是安...

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1: Eur J Neurol. 2009 May 27. [Epub ahead of print]Click here to read

     
    Short- and long-term effects of endurance training in patients with mitochondrial myopathy.
    Jeppesen TD, Dunø M, Schwartz M, Krag T, Rafiq J, Wibrand F, Vissing J.武警总医院神经内科吴士文

    Neuromuscular Research Unit, Department of Neurology, and the Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen, Denmark.

    Background and purpose: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations. Methods: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations. Results: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle. Conclusion: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.

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发表于:2009-06-05 20:03

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