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典型病例

CT引导下125I放射性粒子治疗有症状性后腹膜淋巴结转移

发表者:王忠敏 人已读

AbstractPurpose This study explored the clinical efficacy of CT-
guided radioactive
125 I seed implantation in treating
patients with symptomatic retroperitoneal lymph node
metastases.
Methods Twenty-five patients with pathologically con-
firmed malignant tumors received CT-guided radioactive
125 I seed implantation to treat metastatic lymph nodes. The
diameter of the metastatic lymph nodes ranged from 1.5 to
4.5 cm. Treatment planning system (TPS) was used to
reconstruct the three-dimensional image of the tumor and
then calculate the corresponding quantity and distribution
of
125 I seeds.
Results Follow-up period for this group of patients was
2–30 months, and median time was 16 months. Symptoms
of refractory pain were significantly resolved postimplan-
tation (P\0.05), and Karnofsky score rose dramatically
(P\0.05). Most patients reported pain relief 2–5 days
after treatment. Follow-up imaging studies were performed
2 months later, which revealed CR in 7 patients, PR in 13
patients, SD in 3 patients, and PD in 2 patients. The overall
effective rate (CR ? PR) was 80 %. Median survival time
was 25.5 months. Seven patients died of recurrent tumor;
16 patients died of multiorgan failure or other metastases.
Two patients survived after 30 months follow-up. Two
patients reported localized skin erythema 1 week postim-
plantation, which disappeared after topical treatment.
Conclusions CT-guided radioactive
125 I seed implanta-
tion, which showed good palliative pain relief with accept-
able short-term effects, has proved in our study to be a new,
safe, effective, and relatively uncomplicated treatment
option for symptomatic retroperitoneal metastatic lymph
nodes.
Keywords Retroperitoneal lymph node metastases ?
CT-guided ? Implantation ?
125 I seed ? Brachytherapy

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本文仅供健康科普使用,不能做为诊断、治疗的依据,请谨慎参阅

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发表于:2016-01-03