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内镜下黏膜切除十二指肠腺瘤的安全性和有效性

发表者:常玉英 1108人已读

Gastrointest Endosc. 2017 Feb 28. 

Jamil LH1, Kashani A2, Peter N3, Lo SK2.

Safety and Efficacy of Cap-Assisted Endoscopic Mucosal Resection for Sporadic Nonampullary Duodenal Adenomas.

BACKGROUND AND AIMS:

Eradication of sporadic non-ampullary duodenal adenomas (SNADAs) is essential due to their high rate of malignant transformation. Endoscopic mucosal resection (EMR) techniques are the alternative to the traditional surgical treatments of SNADAs. There are very limited data on the safety and efficacy of cap-assisted EMR (C-EMR) in the treatment of SNADA.四川省第四人民医院消化内科常玉英

METHODS:

The medical records of patients who underwent C-EMR for SNADAs between July 2002 and April 2013 were retrospectively reviewed. Eradication was defined as no residual adenoma on follow-up or en bloc resection on pathology. Recurrence was defined as finding adenoma after a negative follow-up.

RESULTS:

Fifty-nine C-EMR sessions were performed on 49 SNADAs (flat: 46, sessile: 3); 39 polyps were treated in piecemeal fashion and 10 polyps with en bloc resection. The polyp histology was tubular adenoma (63.3%) and tubulovillous adenoma (36.7%) with 16.3% of lesions showing high-grade dysplasia. Initial eradication rate was 90.5%; residual adenomas were successfully treated with repeat C-EMR/snare, resulting in 100% ultimate eradication rate without any recurrences (median follow-up of 17 months). The overall adverse events rate was 16.9%: intraprocedural bleeding (10.2%), delayed GI bleeding (5.1%), and perforation (1.7%). Among large polyps (≥15 mm), the initial and ultimate eradication rates were 87.9% and 100% respectively, and the adverse events rate was 17%. Initial eradication rate for the small polyps was higher than in large polyps (100% vs 87.9%, respectively; P= 0.02).

CONCLUSION:

C-EMR is a highly efficient and safe method for the treatment of SNADAs. We recommend that the endoscopist to learn C-EMR on esophageal, gastric, rectal, or left colonic lesions before attempting in duodenum.

KEYWORDS:

Adenoma; Duodenal Neoplasms; Endoscopic mucosal resection

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发表于:2017-03-08 05:35

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