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胶囊内镜在诊断结肠癌和直肠癌方面的应用

发表者:常玉英 898人已读

Gastroenterol Res Pract. 2017;2017:1507914. 

Accuracy of Colon Capsule Endoscopy in Detecting Colorectal Polyps in Individuals with Familial Colorectal Cancer: Could We Avoid Colonoscopies?

Alvarez-Urturi C1, Fernández-Esparrach G2, Ibáñez IA1, Rodríguez De Miguel C2, Dedeu JM1, Bessa X1, Córdova H2, Pellisé M2, Balaguer F2, Ginés A2, Barranco L1, Araujo IK2, Andreu M1, Llach J2, Castells A2, González-Suarez B2.四川省第四人民医院消化内科常玉英

Background. Individuals with a family history of colorectal cancer (CRC) have an increased risk of CRC. We evaluated the diagnostic yield of CCE in the detection of lesions and also two different colon preparations. 

Methods. A prospective multicenter study was designed to assess CCE diagnostic yield in a cohort of asymptomatic individuals with a family history of CRC. CCE and colonoscopy were performed on the same day by 2 endoscopists who were blinded to the results of the other procedure. 

Results. Fifty-three participants were enrolled. The sensitivity, specificity, PPV, and NPV of CCE for detecting advanced adenomas were 100%, 98%, 67%, and 100%. Sensitivity, specificity, PPV, and NPV of CCE for the diagnosis of individuals with polyps were 87%, 97%, 93%, and 88%, respectively. CCE identify 100% of individuals with significant or advanced lesions. Overall cleanliness was adequate by 60.7% of them. The PEG-ascorbic boost seems to improve colon cleanliness, with similar colonic transit time. 

Conclusion. CCE is a promising tool, but it has to be considered as an alternative technique in this population in order to reduce the number of colonoscopies performed. More studies are needed to understand appropriate screening follow-up intervals and optimize the bowel preparation regimen.

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发表于:2017-03-09 06:41

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