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付强

付强

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经导管封堵术治疗不明原因卒中合并卵圆孔未闭的疗效及预后

发表者:付强 640人已读

引用本文: 付强,郭彩霞,杜丽娟,等.经导管封堵术治疗不明原因卒中合并卵圆孔未闭患者的临床疗效及预后[J]. 中华心血管病杂志, 2018,46(11): 882-886.  DOI: 10.3760/cma.j.issn.0253-3758.2018.11.012首都医科大学附属北京天坛医院心内科付强

经导管封堵术治疗不明原因卒中合并卵圆孔未闭患者的临床疗效及预后

[摘要] 目的 探讨经导管封堵术治疗治疗不明原因卒中合并卵圆孔未闭(PFO)的临床疗效及预后。方法 本研究为前瞻性研究。连续入选20155月至20179月在北京天坛医院心血管内科接受经导管PFO封堵术治疗的不明原因卒中合并PFO患者60例。所有入选患者均经颅多普勒超声(TCD)增强试验证实存在右向左分流。随访观察经导管PFO封堵术成功率、有效封堵率、并发症、脑缺血事件及新发心房颤动的发生情况。结果 本研究最终入选不明原因卒中合并PFO患者60例,其中男性42例,女性18例,年龄24~68(47±11)岁,PFO直径(静息状态)(1.6±0.6mm。术前右向左分流量,中量者11例,大量者48例(其中淋浴状及雨帘状分流者41例)。经导管PFO封堵术成功率为100%(60/60),无严重围手术期并发症。术后随访2-29个月(中位数12个月),术后6个月45例患者完成TCD增强试验随访,其中中、大量残余右向左分流者4例,有效封堵率达91%41/45)。随访期间,仅1例患者脑梗死复发,无新发心房颤动发生。结论 经导管PFO封堵术治疗不明原因卒中合并PFO安全、有效,预后良好。

[关键词]卒中;卵圆孔未闭;经导管封堵术

Efficacy and outcome of transcatheter closure of patent foramen ovale in patients with cryptogenic stroke

[Abstract] Objective To investigate the efficacy and outcome of transcatheter patent foramen ovale (PFO) closure in patients with cryptogenic stroke (CS). Methods Sixty consecutive patients with cryptogenic stroke who undertook transcatheter PFO closure between May 2015 and September 2017 in Beijing Tiantan Hospital were enrolled in this prospective study. Transcranial Doppler (TCD) bubble test was performed and right-left shunt (RLS) was confirmed in all patients. Closure success rate, effective closure rate, complications, recurrence of ischemic stroke and new onset atrial fibrillation were evaluated. Results A total of 60 patients (42 male, age range 24-68 (47±11)years) were included in the study. PFO size (motionless state) was (1.6±0.6)mm. RLS before closure was graded and 11 patients had moderate RLS and 48 patients had large RLS (include 41 patients who experienced shower or curtain effect). Closure success rate was 100% (60/60). No severe complications were observed. At 6 months,45 patients completed TCD bubble test. Of these, 4 patients suffered from moderate to large residual and thus effective closure rate was 91%(41/45).The mean follow-up period was 2-29 (median 12)months. During the follow-up, only 1 patient experienced recurrent cerebral infarction. New onset atrial fibrillation was not detected. Conclusion Transcatheter PFO closure is effective, safe and related with a good outcome in reduction of recurrent CS for patients with PFO.

[Key words] Stroke; Foramen ovale patent; Transcatheter closure   

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发表于:2018-12-06 21:13

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付强的咨询范围: “脑心共患”疾病,特别是卵圆孔未闭相关疾病(青年不明原因卒中,偏头痛,不明原因晕厥),和其他先天性心脏病(房间隔缺损,动脉导管未闭,室间隔缺损)以及先天性肺动静脉瘘的介入诊疗及临床研究。 更多>>