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卢旺盛

卢旺盛

主任医师 副教授
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神经干细胞移植治疗脑梗塞后遗症的临床应用

发表者:卢旺盛 5420人已读

神经干细胞移植治疗脑梗塞后遗症的临床应用

目的:探讨神经干细胞(NSC)移植对脑梗塞后遗症的影响。

方法:2004年6月至2008年6月胚胎神经干细胞移植入同侧基底节区21例脑梗死患者,采用立体定向技术,应用功能独立性的措施(FIM)用于治疗前评价运动功能和寿命,并在治疗后1和6个月对21名患者的生活质量进行评价,如果FIM升高了1点以上被视为有效。好大夫工作室神经外科卢旺盛

结果:临床症状有效率为为80.95%(17/21例)。治疗后1个月FIM得分分别为93.76±6.83 ,明显高于治疗前的91.21±6.42;然而却低于 治疗后6个月,97.45±7.56。患者接受神经干细胞移植没有严重的并发症。

结论:神经干细胞移植可改善脑梗塞后遗症,患者在一定程度上对包括运动功能和生活质量均有改善,当然神经干细胞移植的远期疗效仍需进一步研究。

参考文献:Wangsheng Lu, Zhicao Li. Clinical transplantation of  human embryonic neural stem cells for the treatment of cerebral infarction   sequelae .Neurosurgery Quarterly, Neurosurgery Quarterly. 23(1):58-60, February 2013.

TITLE:Clinical Transplantation of Human Embryonic Neural Stem Cells for the Treatment of Cerebral Infarction Sequelae

Objective: To investigate the effect of embryonic neural stem cell (NSC) transplantation on cerebral infarction sequelae.

Methods: From June 2004 to June 2008, embryonic NSCs were implanted into the ipsilateral basal ganglia region in 21 patients with cerebral infarction, using stereotactic technology. The function independence measure (FIM) was used to evaluate motor function and quality of life in the 21 patients before treatment, and at 1 and 6 months after treatment. FIM was regarded as effective if elevated by 1 point.

Results: Clinical symptoms improved at an effective rate of 80.95% (17/21 cases). The FIM scores were 93.76±6.83 at 1 month after treatment, which was significantly higher than 91.21±6.42 before treatment; however, they were significantly lower than 97.45±7.56 at 6 months after treatment. Patients undergoing embryonic NSC transplantation had no serious complications.

Conclusions: NSC transplantation can improve cerebral infarction sequelae including motor function and living quality in patients to some extent. However, the long-term effect of NSC transplantation still needs further study.

Key Words: neural stem cells, stem cell therapy, sequelae of cerebral infarction, cell transplantation, function independence measure


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发表于:2015-03-02 22:55

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