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咪唑立宾治疗难治性的多发性肌炎1例报道

发表者:吴士文 人已读

 
1: Clin Rheumatol. 2009 Feb;28(2):227-9. Epub 2008 Dec 9.
Successful treatment of refractory polymyositis with the immunosuppressant mizoribine: case report.
Suwa A, Hirakata M, Kaneko Y, Sato S, Suzuki Y, Kuwana M.

Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. asuwa@is.icc.u-tokai.ac.jp解放军总医院第三医学中心(原武警总医院)神经内科吴士文

We describe a patient who presented with polymyositis with anti-Jo-1 antibodies at 18 years after the onset of rheumatoid arthritis and was successfully treated with the immunosuppressive drug mizoribine at the time of exacerbation. She had developed diabetes mellitus, cerebral infarction, and myocardial infarction after high-dose steroid therapy was initiated. Therefore, an immunosuppressant was preferred as the second-line agent. Treatment with 150 mg/day of mizoribine and 8 mg/day of prednisolone resulted in eventual normalization of muscle enzyme levels. Mizoribine is a purine antimetabolite that inhibits T cell activation/proliferation and B cell proliferation. The potential efficacy of mizoribine for polymyositis was suggested by this case.

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发表于:2009-04-11 23:23

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