1: Eur J Neurol. 2009 May 27. [Epub ahead of print]Click here to read
Short- and long-term effects of endurance training in patients with mitochondrial myopathy.
Jeppesen TD, Dunø M, Schwartz M, Krag T, Rafiq J, Wibrand F, Vissing J.
Neuromuscular Research Unit, Department of Neurology, and the Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen, Denmark.
Background and purpose: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations. Methods: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations. Results: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle. Conclusion: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.