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西酞普兰与帕罗西汀治疗抑郁症对照研究

发表者:于君 6321人已读


摘  要:目的:比较西酞普兰与帕罗西汀治疗抑郁症的临床疗效和安全性. 方法:将68例符合中国精神障碍分类与诊断标准第3版抑郁发作诊断标准的患者,随机分为西酞普兰组与帕罗西汀组,疗程6周.用汉密尔顿抑郁量表(HAMD)评定疗效,用副反应量表(TESS)评定不良反应. 结果:西酞普兰组和帕罗西汀组的有效率分别为85.3%和82.4%,两组相仿.但治疗1周及2周后,西酞普兰组的有效率高于帕罗西汀组.两组间不良反应比较差异无显著性. 结论:西酞普兰是一种起效较快,且安全、有效的新型抗抑郁药.

烟台市莱州荣军医院精神科于君

 

[Abstract] Objective To compare clinical effect and safety of citalopram and paroxetine in the treatment of major depressive episode. Methods Sixty-eight patients who met the criteria of CCMD-3 for depressive episode were randomly divided into subgroups receiving treatment of citalopram and paroxetine respectively for six weeks. The efficacy was assessed by Hamilton depression rating scale(HAMD) and the safety was assessed by treatment emergent symptom scale(TESS). Results After 6 weeks treatment,the effective rate of the citalopram group and the paroxetine group were 85.29% and 82.35%,respectively.The results have no remarkable differences in two groups. The effective rate of citalopram group was higher than that of paroxetine group both after 1 week treatment and after 2 weeks treatment. After 6 weeks treatment, the scores of HAMD in two groups were statistical difference before and after treatment. There was no significant difference between two groups. Both the deceased scores of HAMD and the decreased subscores of HAMD in anxiety somatization and sleep disturbance in citalopram group were lower than that in paroxetine group after 1 week treatment and after 2 weeks treatment. There was no significant difference between two groups. The main adverse reactions of citalopram group were disgust,perspire to increase,etc. Adverse reactions were no obvious difference between two groups. Conclusion Citalopram is a safe and effective, and rapidly responded new antidepressant.

 

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发表于:2009-10-05 09:57

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